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Dr. PI's gallery of Mycobacterium tuberculosis molecules

function |  structure |  protein |  dna |  map |  ref   

  © 2005 blueTB, Dr. PI Bioconsulting

Welcome to blueTB, Dr. PI's gallery of Mycobacterium tuberculosis* molecules. For each Mycobacterium tuberculosis protein listed in blueTB you find information about function, structure, protein features, dna sequence, map position as well as a reference to a scientific article. Click the bar above to see the respective section. Use this page as bookmark for all blueTB molecule entries and the blueTB pathways. This site is best viewed on a Mac with Safari or on a PC with Firefox, popup windows enabled. To view the 3D structural models on these pages you need Jmol. Entries in bold have a description of structure and function.


functional classification of blueTB proteins

function color   energy metabolism, glycolysis: phosphoglycerate mutase, PGAM
function color   energy metabolism, pyruvate dehydrogenase: dihydrolipoamide dehydrogenase, LPDA
function color   energy metabolism, tricarboxylic acid cycle: citrate lyase beta subunit, CitE
function color   energy metabolism, glyoxylate bypass: isocitrate lyase, ICL
function color   energy metabolism, glyoxylate bypass: malate synthase G, glcB
function color   energy metabolism, pentose phosphate pathway: ribose-5-phosphate isomerase, RpiB
function color   energy metabolism, respiration: hemoglobinlike protein HbN
function color   energy metabolism, respiration: hemoglobinlike protein HbO, GLBO
function color   energy metabolism, respiration: NADPH-ferredoxin reductase, FprA
function color   miscellaneous oxidoreductase: peptide methionine sulfoxide reductase, MsrA
function color   amino acid biosynthesis, glutamate family: glutamine synthase 1, GlnA1
function color   amino acid biosynthesis, aspartate family: dihydrodipicolinate reductase, DapB
function color   amino acid biosynthesis, aspartate family: diaminopimelate decarboxylase, LysA
function color   aromatic amino acid biosynthesis: 3-dehydroquinate dehydratase, AroQ, AroD
function color   aromatic amino acid biosynthesis: shikimate kinase, AroK
function color   aromatic amino acid biosynthesis, histidine: ATP phosphoribosyltransferae, HisG
function color   branched chain amino acid biosynthesis: 2-isopropylmalate synthase, LeuA
function color   branched chain amino acid biosynthesis: 3-isopropylmalate dehydrogenase, LeuB
function color   biosynthesis of nucleotides, NTPs: guanylate kinase, Gmk
function color   biosynthesis of nucleotides, dNTPs: deoxyuridine triphosphatase, dUTPase
function color   biosynthesis of nucleotides, dNTPs: ribonucleotide reductase R2-2 small subunit, nrdF1
function color   biosynthesis of nucleotides, dNTPs: thymidilate kinase, tmk
function color   biosynthesis of nucleotides, salvage: purine nucleoside phosphorylase, punA, deoD
function color   biosynthesis of nucleotides, miscellaneous: 3-dehydroquinate dehydratase, Adk
function color   biosynthesis of nucleotides, miscellaneous: nucleoside diphosphate kinase, NdkA
function color   biosynthesis of cofactors, NAD: quinolinate phosphoribosyl transferase, NadC
function color   biosynthesis of cofactors, folic acid: dihydropteroate synthase 1, folP1
function color   biosynthesis of cofactors, folic acid: dihydroneopterin aldolase, folB
function color   biosynthesis of cofactors, folic acid: dihydrofolate reductase, folA
function color   biosynthesis of cofactors, folic acid: methylenetetrahydrofolate dehydrogenase/cyclohydrolase, folD
function color   biosynthesis of cofactors, panthotenate: 3-methyl-2-oxobutanoate hydroxymethyltransferase , panB
function color   biosynthesis of cofactors, panthotenate: pantothenate synthetase, panC
function color   biosynthesis of cofactors, mycothiol: mycothiol synthase, MshD
function color   biosynthesis of cofactors, menaquinone: naphthoate synthase, MenB
function color   synthesis of fatty and mycolic acids: β-ketoacyl-ACP synthase III, FabH
function color   synthesis of fatty and mycolic acids: enoyl-[ACP]-reductase, InhA
function color   synthesis of fatty and mycolic acids: meromycolate extension acyl carrier protein, acpM
function color   synthesis of fatty and mycolic acids: 3-alpha, 20-beta hydroxysteroid dehydrogenase, HSD
function color   modification of fatty and mycolic acids: mycolic acid synthase, PcaA
function color   modification of fatty and mycolic acids: cyclopropane mycolic acid synthase 1, CmaA1
function color   modification of fatty and mycolic acids: cyclopropane mycolic acid synthase 2, CmaA2
function color   modification of fatty and mycolic acids: methoxy mycolic acid synthase 2, MmaA2
function color   lipid biosynthesis; mycolyltransferases: antigen 85A, mycolyltransferase, Ag85A
function color   lipid biosynthesis; mycolyltransferases: antigen 85B, mycolyltransferase, Ag85B
function color   lipid biosynthesis; mycolyltransferases: antigen 85C, mycolyltransferase, Ag85C
function color   polyketide biosynthesis; polyketide synthase Pks18
function color   polyketide biosynthesis; phenolpthiocerol synthesis type-1 polyketide synthase, PpsC
function color   polyketide biosynthesis; polyketide-associated protein PapA5
function color   repressors/activators: iron dependent repressor and activator, IdeR
function color   repressors/activators: pyrimidine biosynthesis regulatory protein, PyrR
function color   repressors/activators: transcriptional regulatory repressor protein, EthR
function color   repressors/activators: putative transcriptional antiterminator
function color   serine-threonine protein kinases, PknB
function color   serine-threonine protein kinases, PknD
function color   serine-threonine protein phosphatase, PSTP/PPP
function color   DNA replication, repair, recombination: single-strand binding protein, SSB
function color   DNA replication, repair, recombination: recombinase A, RecA
function color   protein translation and modification: peptidyl-prolyl cis-trans isomerase A
function color   synthesis of RNA, N-utilization substance protein B homolog, NusB
function color   synthesis of RNA, transcription elongation factor, NusA
function color   synthesis of RNA, t-RNA pseudouridine synthase B, TruB
function color   degradation of RNA, Regulator of ribonuclease activity A, MenG
function color   degradation of polysaccharides: cellulase / endoglucanase, CelA1
function color   cell envelope, antigens: major secreted immunogenic protein, MPT70
function color   cell envelope, antigens: soluble secreted antigen, MPT53
function color   cell envelope, membrane proteins: large conductance mechanosensitive channel, MscL
function color   cell envelope, membrane proteins: phosphopantetheine adenylyltransferase, PPAT
function color   cell envelope, membrane proteins: dTDP-4-dehydrorhamnose 3,5-epimerase, RMLC
function color   cell processes, transport / binding of anions: phosphate binding protein 1, PhoS1
function color   chaperones/heat shock: 60 kDa chaperonin 2, Cpn60-2, GroEL2
function color   chaperones/heat shock: 10 kDa chaperonin, Cpn10, GroES
function color   cell division: cell division protein, FtsZ
function color   cell processes: protein and peptide secretion, SecA1
function color   cell detoxification: catalase peroxidase T, KatG
function color   cell detoxification: superoxide dismutase [Cu-Zn], SodC
function color   cell detoxification: superoxide dismutase [Fe], SodB
function color   cell detoxification: alkylhydroperoxidase, AhpD
function color   cell detoxification: thiol peroxidase, Tpx
function color   other functions, antibiotic production and resistance: GlcNAc-Ins deacetylase, MshB
function color   other functions, cytochrome P450 enzymes: 14-α-sterol demethylase, Cyp51
function color   other functions, cytochrome P450 enzymes: Cyp121
function color   unknown function, antigen 85C1, Ag85C1
function color   unknown function, antigen MPT63
function color   unknown function, conserved hypothetical protein Rv1155
function color   unknown function, conserved hypothetical protein TB15.3, Rv1636
function color   unknown function, possible RNA methyltransferase
function color   myo-inositol-1-phosphate synthase, Ino
function color   inorganic polyphosphate/ATP-NAD-kinase, PpnK
function color   ADPR pyrophosphatase, ADPRase
function color   hypothetical protein Rv2991




*about Mycobacterium tuberculosis

Tuberculosis is still a major public health problem worldwide. Approximately one third of the world's population is infected with Mycobacterium tuberculosis and is at risk of developing the disease. For more information on TB view the W.H.O. pages. The genomic sequence of M. tuberculosis is known since 1998 and the open reading frames have been annotated. A multitude of functions of Mtb antigens, lipids, specific carbohydrates and several mechanisms of virulence have been described. The purpose of these blueTB pages is to give a portrait of each Mycobacterium tuberculosis molecule, whose threedimensional structure is known and to explain the functional properties of the protein based on its structural features. Of special interest are the genes that are putative virulence factors or responsible for the susceptibility of the tubercle bacilli towards antituberculous drugs. Another challenge is to identify genes that are regulating the state of latency in M. tuberculosis in response to the host environment and maintain it for long time periods, thus allowing persistance and reactivation of tuberculosis.

Several candidates for new drug targets have been identified by the scientific community and the crystal structures of the corresponding proteins give new insights into the microbial metabolism and identify reactions that are unique to M. tuberculosis. This blueTB collection of Mycobacterium tuberculosis molecules is meant to serve you as a portal into the fascinating world of microbial life at the molecular level.

enjoy!





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To view the structure* of a blueTB molecule as a Jmol 3D-structural model, click on the image of a protein

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*about structure

Chemical structure is the arrangement of atoms within a molecule. For simple molecules the chemical structure can be represented using a structural formula. Structure can range from relatively simple molecules, such as biochemicals, to very complex structures, such as protein, carbohydrate or nucleic acid molecules. The structure of a molecules is the basis for its specific functions.

In proteins the primary protein structure is the sequence of a chain of amino acids. Stretches of this chain can form secondary structures like α-helices of pleated sheets that are stabilized by hydrogen bonds between the participating amino acids. The spatial relationship of the secondary structures make up the overall shape of a singe protein molecule, the tertiary structure. If a protein complex is made up of more than one protein subunit, ists structure is named quaternary structure. The threedimensional structure of molecules (small or large) can be visualized on the web with Jmol, a free, open source molecule viewer for students, educators, and researchers in chemistry and biochemistry. It is cross-platform, running on Windows, Mac OS X, and Linux/Unix systems.

To determine the macromolecular structure of a protein is a difficult task because a protein contains hundreds or thousands of atoms. Protein structures can be experimentelly derived by X-ray diffraction of a protein crystal, where the diffraction pattern depends on the position of individual atoms. From this pattern a list of coordinates for individual atoms is calculated and deposited as a file in a structure database. Alternatively it is sometimes possible to determine the structure of a protein in aequous solution by biomolecular NMR(nuclear magnetic resoncance) structure analysis. The TB structural genomics consortium is solving the structures of many M.tb molecules and make them available to the public. Dr. PI's gallery of Mycobacterium tuberculosis molecules refers to the structural data of M. tuberculosis enzymes and other proteins that have been submitted to Protein Data Bank with the purpose to explain the functional properties of the protein based on its structural features.

 

 

page number in Dr. PI's Mtbook

page 4, Rv0009, ppiA, peptidyl-prolyl cis-trans isomerase A
page 6, Rv0014c, pknB, serine-threonine protein kinase
page 7, Rv0018c, PSTP/PPP, serine-threonine protein phosphatase
page 16, Rv0046c, ino, myo-inositol-1-phosphate synthase
page 19, Rv0054, SSB, single-strand binding protein
page 21, Rv0062, celA1, cellulase / endoglucanase
page 49, Rv0129c, fbpC, Ag85C, antigen 85C, mycolyltransferase
page 51, Rv0137c, MsrA, peptide methionine sulfoxide reductase
page 161, Rv0432, SodC, superoxide dismutase [Cu-Zn]
page 164, Rv0440, GroEL2, 60 kD chaperonin 2
page 173, Rv0467, AceA, ICL, isocitrate lyase
page 174, Rv0470c, PcaA, UmaA2, CmaC, mycolic acid synthase
page 179, Rv0489, PGAM, GpmA, phosphoglycerat mutase
page 184, Rv0503c, CmaA2, cyclopropane mycolic acid synthase 2
page 193, Rv0533c, β-ketoacyl-ACP synthase III
page 198, Rv0548c, MenB, naphthoate synthase
page 255, Rv0733, Adk, adenylate kinase
page 256, Rv0764c, 14-α-sterol demethylase
page 228, Rv0470c, MmaA2 methoxymycolic acid synthase 2
page 282, Rv0819, MshD, mycothiol synthase
page 321, Rv0931c, pknD, serine-threonine protein kinase
page 322, Rv0934,PhoS1, phosphate binding protein 1
page 340, Rv0985c, MscL, large conductance mechanosensitive channel
page 396, Rv1155, conserved hypothetical protein Rv1155
page 402, Rv1170, MshB, GlcNAc-Ins deacetylase
page 448, Rv1293, LysA, diaminopimelate decarboxylase
page 477, Rv1372, Pks18, polyketide synthase
page 480, Rv1379, PyrR, pyrimidine biosynthesis regulatory protein
page 483, Rv1389, Gmk, guanylate kinase
page 517, Rv1484, InhA, enoyl-[ACP]-Reductase
page 539, Rv1542c, HbN, hemoglobinlike protein
page 555, Rv1596, NadC, quinolinate phosphoribosyl transferase
page 565, Rv1626, putative transcriptional antiterminator
page 569, Rv1636, hypothetical protein TB15.3
page 593, Rv1695, PpnK, inorganic polyphosphate/ATP-NAD-kinase
page 595, Rv1700, ADPRase, ADP pyrophosphatase
page 644, Rv1837c, GlcB, malate synthase G
page 660, Rv1886c, FbpB, Ag85B, antigen 85B, mycolyltransferase
page 665, Rv1908c, KatG, catalase-peroxidase T
page 673, Rv1926c, antigen MPT63
page 674, Rv1932, Tpx, thiol peroxidase
page 694, Rv2002, HSD, 3-alpha, 20-beta hydroxysteroid dehydrogenase
page 734, Rv2118c, possible RNA methyltransferase
page 735, Rv2121c, ATP-PRT, ATP phosphoribosyltransferase
page 744, Rv2150c, FtsZ, cell division protein
page 768, Rv2220, GlnA1, glutamine synthase 1
page 771, Rv2225, KPHMT, 3-methyl-2-oxobutanoate hydroxymethyltransferase
page 774, Rv2244, AcpM, meromycolate extension acyl carrier protein
page 787, Rv2276, Cyp121, cytochrome P-450 121
page 842, Rv2429, AhpD, alkylhydroperoxidase
page 848, Rv2445c, NdkA, nucleoside diphosphate kinase
page 855, Rv2465c, RpiB, ribose-5-phosphate isomerase
page 856, Rv2470, GlbO, hemoglobin-like protein HbO
page 869, Rv2498c, CitE, citrate lyase beta subunit
page 883, Rv2533c, NusB, N-utilization substance protein B homolog
page 884, Rv2537c, AroQ, AroD, 3-dehydroquinate dehydratase
page 884, Rv2539c, AroK, shikimate kinase
page 931, Rv2697c, dUTPase, deoxyuridine triphosphatase
page 934, Rv2711, IdeR, Iron dependent repressor and activator
page 942, Rv2737c, RecA, recombinase A
page 949, Rv2763c, FolA, dihydrofolate reductase
page 952, Rv2773c, DapB, dihydrodipicolinate reductase
page 958, Rv2793c, TruB, tRNA pseudouridine synthase B
page 972, Rv2841c, NusA, transcription elongation factor nusA
page 984, Rv2875, MPT70, major secreted immunogenic protein
page 985, Rv2878c, MPT53, soluble secreted antigen
page 1005, Rv2933, PpsC, phenolpthiocerol synthesis type-1 polyketide synthase
page 1011, Rv2939, PapA5, polyketide-associated protein
page 1025, Rv2965c, PPAT, phosphopantetheine adenylyltransferase
page 1034, Rv2991, hypothetical protein
page 1035, Rv2995c, LeuB, IMDH, 3-isopropylmalate dehydrogenase
page 1052, Rv3048c, NrdF1, R2F-2, ribonucleotide reductase R2-2 small subunit
page 1073, Rv3106, FprA, NFR, NADPH-ferredoxin reductase
page 1117, Rv3240c, SecA1, preprotein translocase secA 1 subunit
page 1120, Rv3247c, TMPK, thymidilate kinase
page 1139, Rv3303c, LPDA, dihydrolipoamide dehydrogenase
page 1141, Rv3307, PNP, purine nucleoside phosphorylase
page 1164, Rv3356c, FolD, methylenetetrahydrofolate dehydrogenase/cyclohydrolase
page 1176, Rv3392c, CMAS1, cyclopropane mycolic acid synthase 1
page 1185, Rv3418c, Cpn10, GroES, 10 kDa chaperonin
page 1199, Rv3465, RMLC, dTDP-4-dehydrorhamnose 3,5-epimerase
page 1249, Rv3602c, PanC, pantothenate synthetase
page 1250, Rv3607c, DHNA, dihydroneopterin aldolase
page 1250, Rv3608c, DHPS 1, dihydropteroate synthase
page 1283, Rv3710, LeuA, 2-isopropylmalate synthase
page 1317, Rv3803c, FbpC1, Ag85C1, antigen 85C1
page 1317, Rv3804c, FfbpA, Ag85A, antigen 85A, mycolyltransferase
page 1334, Rv3846, SodB, superoxide dismutase [Fe]
page 1336, Rv3853, MenG, rraA, regulator of ribonuclease activity A
page 1336, Rv3854, EthR, transcriptional regulatory repressor protein


blueTB entries in chronological order (entries in bold have description of structure and function)

0001. InhA, Rv1484, Enoyl-[ACP]-Reductase [January 2005]
0002. IdeR, Rv2711, Iron dependent repressor and activator [February 2005]
0003. FtsZ, Rv2150c, Cell division protein [February 2005]
0004. Cpn10, GroES, Rv3418, 10 kDa chaperonin [March 2005]
0005. AroQ, Rv2537, 3-dehydroquinate dehydratase [March 2005]
0006. EthR, Rv3855, transcriptional regulatory repressor protein[April 2005]
0007. AG85A, FbpA, Rv3804c, antigen 85A, mycolyltransferase, fibronectin binding protein A [May 2005]
0008. AG85B, FbpB, Rv1886c, antigen 85B, mycolyltransferase, fibronectin binding protein B [May 2005]
0009. AG85C, FbpC, Rv0129c, antigen 85C, mycolyltransferase, fibronectin binding protein C [May 2005]
0010. AG85C1, FbpC1, Rv3803c [May 2005]
0011. Ino, FbpC1, Rv0046c, myo-inositol-1-phosphate synthase [May 2005]
0012. SSB, Rv0054, single-strand binding protein [May 2005]
0013. CelA1, Rv0062, cellulase / endoglucanase [May 2005]
0014. PknB, Rv0014c, serine-threonine protein kinase [May 2005]
0015. MsrA, Rv0137c, peptide methionine sulfoxide reductase [May 2005]
0016. SodC, Rv0432, superoxide dismutase [Cu-Zn] [May 2005]
0017. GroEL2, Rv0440, 60 kD chaperonin 2 [May 2005]
0018. ICL, AceA, Rv0467, isocitrate lyase [May 2005]
0019. PcaA, UmaA2, CmaC, mycolic acid synthase [May 2005]
0020. PGAM, gpmA,phosphoglycerate mutase I [May 2005]
0021. CmaA2, Rv0503c, cyclopropane mycolic acid synthase 2 [June 2005]
0022. FabH, Rv0533c, β-ketoacyl-ACP synthase III [June 2005]
0023. MenB, Rv0548c, naphthoate synthase [June 2005]
0024. MmaA2, Rv0644c, methoxymycolic acid synthase 2 [June 2005]
0025. Adk, Rv0733, adenylate kinase [June 2005]
0026. CYP51, Rv0764c, 14-α-sterol demethylase [June 2005]
0027. MshD, Rv0819, mycothiol synthase [June 2005]
0028. PknD, Rv0931c, serine threonine protein kinase [June 2005]
0029. PhoS1, Rv0934, phosphate binding protein 1 [June 2005]
0030. MscL, Rv0985c, large conductance mechanosensitive channel [June 2005]
0031. MenG, rraA, Rv3853c, Regulator of ribonuclease activity A [August 2005]
0032. SodB, Rv3848c, superoxide dismutase [Fe] [September 2005]
0033. MshB, Rv1170, GlcNAc-Ins deacetylase [September 2005]
0034. LysA, Rv1293, diaminopimelate decarboxylase [September 2005]
0035. Pks18, Rv1372, polyketide synthase [September 2005]
0036. PyrR, Rv1379, pyrimidine biosynthesis regulatory protein [September 2005]
0037. KatG, Rv1908c, catalase-peroxidase [September 2005]
0038. HbN, Rv1542c, hemoglobinlike protein [September 2005]
0039. NadC, Rv1596, quinolinate phosphoribosyl transferase [September 2005]
0040. Rv1626, putative transcriptional antiterminator [September 2005]
0041. Rv1926c, antigen MPT63 [September 2005]
0042. Rv1695, inorganic polyphosphate/ATP-NAD-kinase [September 2005]
0043. ADPRase, Rv1700, ADP pyrophosphatase [October 2005]
0044. GlcB, Rv1837c, malate synthase G [October 2005]
0045. PpiA, Rv0009, peptidyl-prolyl cis-trans isomerase [October 2005]
0046. LeuA, Rv3710, 2-isopropylmalate synthase [October 2005]
0047. DHPS 1, Rv3608c, dihydropteroate synthase [October 2005]
0048. DHNA, Rv3607c, dihydroneopterin aldolase [October 2005]
0049. HSD, Rv2002, 3-alpha, 20-beta hydroxysteroid dehydrogenase [October 2005]
0050. Rv2118c, possible RNA methyltransferase [October 2005]
0051. ATP-PRT, HisG, Rv2121c, ATP phosphoribosyltransferase [November 2005]
0052. GlnA1, Rv2220, glutamine synthase 1 [November 2005]
0053. KPHMT, PanB, Rv2225, 3-methyl-2-oxobutanoate hydroxymethyltransferase [November 2005]
0054. acpM, Rv2244, meromycolate extension acyl carrier protein [November 2005]
0055. PanC, Rv3602c, pantothenate synthetase [November 2005]
0056. cyp121, Rv2276, cytochrome P-450 121 [November 2005]
0057. ahpD, Rv2429, alkylhydroperoxidase [November 2005]
0058. ndkA, Rv2445c, nucleoside diphosphate kinase [November 2005]
0059. rpiB, Rv2465c, ribose-5-phosphate isomerase [November 2005]
0060. glbO, Rv2470, hemoglobin-like protein HbO [November 2005]
0061. citE, Rv2498c, citrate lyase beta subunit [December 2005]
0062. nusB, Rv2533c, N-utilization substance protein B homolog [December 2005]
0063. aroK, Rv2539c, shikimate kinase [December 2005]
0064. dut, Rv2697c, deoxyuridine triphosphatase [December 2005]
0065. recA, Rv2737c, recombinase A [December 2005]
0066. folA, Rv2763c, dihydrofolate reductase [December 2005]
0067. dapB, Rv2773c, dihydrodipicolinate reductase [December 2005]
0068. truB, Rv2793c, tRNA pseudouridine synthase B [December 2005]
0069. nusA, Rv2841c, transcription elongation factor [December 2005]
0070. mpt70, Rv2875, major secreted immunogenic protein [December 2005]
0071. mpt53, Rv2878c, soluble secreted antigen [January 2006]
0072. ppsC, Rv2933, phenolpthiocerol synthesis type-1 polyketide synthase [January 2006]
0073. papA5, Rv2939, polyketide-associated protein [January 2006]
0074. coaD, Rv2965c, phosphopantetheine adenylyltransferase [January 2006]
0075. LeuB, IMDH, Rv2995c, 3-isopropylmalate dehydrogenase [January 2006]
0076. NrdF2, R2F-2, Rv3048c, ribonucleotide reductase R2-2 small subunit [January 2006]
0077. fprA,NFR, Rv3106, NADPH-ferredoxin reductase [January 2006]
0078. secA1, Rv3240c, preprotein translocase secA 1 subunit [January 2006]
0079. tmk, TMPK, Rv3247c, thymidilate kinase [January 2006]
0080. lpdA, Rv3303c, dihydrolipoamide dehydrogenase [January 2006]
0081. punA, deoD, PNP, Rv3307, purine nucleoside phosphorylase [February 2006]
0082. cmaA1, CMAS 1, Rv3392c, cyclopropane mycolic acid synthase 1 [February 2006]
0083. rmlC, Rv3465, dTDP-4-dehydrorhamnose 3,5-epimerase [February 2006]
0084. PSTP/PPP, Rv018c, serine/threonine protein phosphatase [February 2006]
0085. Rv1155, conserved hypothetical protein [February 2006]
0086. Gmk,Rv1389, guanylate kinase [February 2006]
0087. uspA, Rv1389, hypothetical protein TB15.3 [February 2006]
0088. Tpx, Rv1932, thiol peroxidase [February 2006]
0089. FolD, Rv3356c, methylenetetrahydrofolate dehydrogenase/cyclohydrolase [February 2006]
0090. Rv2991, hypothetical protein [February 2006]



blueTB molecules are published by Paul Imboden, Dr. PI Bioconsulting. Comments and suggestions are welcome: contact me. Authorization to photocopy or reproduce this entry for personal use is granted provided its content is not modified. Copyright @ 2005 Paul Imboden, Dr. PI Bioconsulting. Last modified December 3, 2009 . References for blueTB entries are:

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Barrell BG, et al. Nature, 393:537-44 (1998) and the Mycobacterium tuberculosis sequencing project from the Sanger Centre.

Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.
Fleischmann RD, Alland D, Eisen JA, Carpenter L, White O, Peterson J, DeBoy R, Dodson R, Gwinn M, Haft D, Hickey E, Kolonay JF, Nelson WC, Umayam LA, Ermolaeva M, Salzberg SL, Delcher A, Utterback T, Weidman J, Khouri H, Gill J, Mikula A, Bishai W, Jacobs Jr WR Jr, Venter JC, Fraser CM. J Bacteriol. 184:5479-90 (2002) and the Mycobacterium tuberculosis sequencing project from TIGR .

3. Dr. PI's Mtbook, The Mycobacterium tuberculosis genome in a book. Paul Imboden, Dr.PI Bioconsulting.
mtbook.drpi.ch/
Release 1.8.0 Jan 2004, which itself is based mainly on reference 1.

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