Mycobacterium tuberculosis strain π Mycobacterium tuberculosis strain π blueTB molecules protein image

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is involved in the . It has the Enzyme Activity and belongs to the CFA-synthase . catalyses the following reaction.

S-adenosyl-L-methionine
+ phospholipid olefinic fatty acid

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S-adenosyl-L-homocysteine
+ phospholipid cyclopropane fatty acid


structure >

 

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The structural model was obtained from PDB entry , and the description from . Click here to search for at PDB.

protein >

is a peptide of with a and a The amino acid composition shows relatively high levels of tyrosine. The sequence contains a S-adenosyl-L-methionine-binding motif at position 76-84. Cys284 seems to be essential for catalysis. The sequence contains several .

Intragenome comparison reveals a multitude of homologous genes in mainly to other proteins of the like the cyclopropane mycolic acid synthase A1 (cmaA2), the methoxymycolic acid synthases (mmaA3, mmaA2, mmaA4 and mmaA1), unknown mycolic acid synthase (umaA1 and umaA2) and - to a lesser degree - to many methyl transferases. Similarly the search for homologues in revelas homology to very many methyltransferases and cyclopropane synthases from various organisms. More functional links are available from the .

 

dna >

The gene is encoded in a In the M. tuberculosis laboratory strain H37Rv it is a known as which corresponds to gene in the clinical isolate CDC 1551. It can be found on .

 

map >

On the circular M. tuberculosis chromosome lies at .

 

ref >

The following tuberculosis-searches could provide additional information for this specific blueTB entry: To obtain a printable version of this blueTB entry click printVersion. Click the reload button to switch back to sectional view.

blueTB molecules are published by Paul Imboden, Dr. PI Bioconsulting. Authorization to photocopy or reproduce this entry for personal use is granted. Copyright @ 2005 Paul Imboden, Dr. PI Bioconsulting. Last modified May 17, 2008 . Disclaimer: blueTB and the author reserves the right to modify and cancel any statement in these documents and regrets, that he cannot accept any responsibility for the consequences of any such changes. to the best of my knowledge all information is correct, but I cannot accept liability for any errors. References for this blueTB entry are:

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Barrell BG, et al. Nature, 393:537-44 (1998) and the Mycobacterium tuberculosis sequencing project from the Sanger Centre.

Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains. Fleischmann RD, Alland D, Eisen JA, Carpenter L, White O, Peterson J, DeBoy R, Dodson R, Gwinn M, Haft D, Hickey E, Kolonay JF, Nelson WC, Umayam LA, Ermolaeva M, Salzberg SL, Delcher A, Utterback T, Weidman J, Khouri H, Gill J, Mikula A, Bishai W, Jacobs Jr WR Jr, Venter JC, Fraser CM. J Bacteriol. 184:5479-90 (2002) and the Mycobacterium tuberculosis sequencing project from TIGR .

3. Dr. PI's Mtbook, The Mycobacterium tuberculosis genome in a book. Paul Imboden, Dr.PI Bioconsulting. mtbook.drpi.ch/ Release 1.8.0 Jan 2004, which itself is based mainly on reference 1.

Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis. Huang CC, Smith CV, Glickman MS, Jacobs WR Jr, Sacchettini JC. J Biol Chem. 277:11559-11569. (2002)
 

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