Mycobacterium tuberculosis strain π Mycobacterium tuberculosis strain π blueTB molecules protein image

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is part of the and belongs to the cyclopropane-fatty-acyl-phospholipid synthase which is part of the methyltransferase superfamily. It catalyses the reaction (see also CmaA2).

S-adenosyl-L-methionine
+ phospholipid olefinic fatty acid

<=>

S-adenosyl-L-homocysteine
+ phospholipid cyclopropane fatty acid

structure >

 

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The structural model was obtained from PDB entry , and the description from . Click here to search for at PDB.

protein >

is a peptide of with a and a The amino acid composition shows relatively high amounts of phenyalanine and histidine. The sequence contains several .

Intragenome comparison identifies multiple genes in with very high homology, namely the cyclopropane mycolic acid synthases (cmaA1), theother methoxymycolic acid synthases (mmaA1, mmaA3, mmaA4), unknown mycolic acid methyltransferases (umaA1, umaA2) and many other (methyl-)transferases. Homologues in are mostly cyclopropane fatty-acyl phospholipid synthases. More functional links are available from the .

dna >

The gene is encoded in a In the M. tuberculosis laboratory strain H37Rv it is a known as which corresponds to gene in the clinical isolate CDC 1551. It can be found at the bottom of and the following page.

 

map >

On the circular M. tuberculosis chromosome lies at next to mmaA3, mmaA2 and mmaA1.

 

ref >

The following tuberculosis-searches could provide additional information for this specific blueTB entry: To obtain a printable version of this blueTB entry click printVersion. Click the reload button to switch back to sectional view.

blueTB molecules are published by Paul Imboden, Dr. PI Bioconsulting. Authorization to photocopy or reproduce this entry for personal use is granted. Copyright @ 2005 Paul Imboden, Dr. PI Bioconsulting. Last modified May 17, 2008 . Disclaimer: blueTB and the author reserves the right to modify and cancel any statement in these documents and regrets, that he cannot accept any responsibility for the consequences of any such changes. to the best of my knowledge all information is correct, but I cannot accept liability for any errors. References for this blueTB entry are:

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Barrell BG, et al. Nature, 393:537-44 (1998) and the Mycobacterium tuberculosis sequencing project from the Sanger Centre.

Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains. Fleischmann RD, Alland D, Eisen JA, Carpenter L, White O, Peterson J, DeBoy R, Dodson R, Gwinn M, Haft D, Hickey E, Kolonay JF, Nelson WC, Umayam LA, Ermolaeva M, Salzberg SL, Delcher A, Utterback T, Weidman J, Khouri H, Gill J, Mikula A, Bishai W, Jacobs Jr WR Jr, Venter JC, Fraser CM. J Bacteriol. 184:5479-90 (2002) and the Mycobacterium tuberculosis sequencing project from TIGR .

3. Dr. PI's Mtbook, The Mycobacterium tuberculosis genome in a book. Paul Imboden, Dr.PI Bioconsulting. mtbook.drpi.ch/ Release 1.8.0 Jan 2004, which itself is based mainly on reference 1.

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