Mycobacterium tuberculosisi strain &pi blueTB pathways

aro

aromatic amino acid biosynthesis

pathway

part 1  |   part 2  |   part 3  |   molecules  

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Click on the pathway overview scheme to view the reactions of a specific branch. blueTB reaction charts are interactive; clicking on a formula brings up a 3D-molecular model of the corresponding structure, clicking on a enzyme name shows its entry in the KEGG Enzyme database. The name of the coding gene is listed in bold on the right side. In case the structure of the corresponding Mycobacterium tuberculosis protein has been solved, the gene name is underlined and its blueTB entry can be accessed by clicking.

pathway overview par3 part2 part1

copyright Paul Imboden, Dr. PI Bioconsulting


   

part1 |  aroB |  aroQ |  aroE |  aroK |  aroA |  aroC |  aro pathway  

from erythrose 4-phosphate to chorismate

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reactions1 anchor AroQ formula nonenzymatic reaction enzyme formula AroK formula enzyme formula formula formula formula formula formula formula formula enzyme enzyme formula formula formula formula enzyme formula enzyme formula formula formula formula formula

   

part2 |  aroH, pheA |  pheA |  tyrA |  tat |  pah |  aro pathway  

from chorismate to phenylalanine and tyrosine

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reactions2 formula formula formula formula formula formula formula formula formula formula formula formula formula formula formula formula formula formula formula part2 enzyme enzyme enzyme enzyme enzyme

The atoms labelled in red are derived from the phosphoenolpyruvate added in the first aro reaction, those in blue are derived from the second PEP added, the others came from erythrose-4-phosphate.

 


   

part 3 |  trpE, G, D |  trpD |  trpF, C |  trpC |  trpA, B |  aro pathway  

from chorismate to tryptophan

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reactions3 formula formula formula formula formula formula formula formula formula formula formula formula formula formula formula enzyme enzyme enzyme enzyme enzyme part3

   

molecules |  part 1  |   part 2  |   part 3  |   aro pathway  

enzymes and biochemicals in the aro pathway

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Click on a underlined enzyme to go to the description of the corresponding Mycobacterium tuberculosis protein in Dr. PI's blueTB website.

  • aro part 1
  • aro part 2
    • chorismate mutase, aroH
    • prephenate dehydratase, pheA
    • prephenate dehydrogenase, tyrA
    • tyrosine transaminase, tat
    • phenylalanine 4-monooxygenase, pah

  • aro part 3
    • anthranilate synthase, trpE, trpG
    • anthranilate phosphoribosyltransferase, trpD
    • phosphoribosyl-anthranilate isomerase, trpC, trpF
    • indole 3-glycerolphosphate-synthase, trpC
    • tryptophan synthase, trpAB
anchor AroQ formula nonenzymatic reaction enzyme formula AroK formula enzyme formula formula formula formula formula formula formula formula enzyme enzyme formula formula formula formula enzyme formula enzyme formula formula formula formula formula

alphabetical list of the biochemical molecules involved in the aromatic amino acid pathways. Click on a substance name to go to the section on this page, where it is used.

   

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