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blueTB pathways | |||
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pathway |
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Click on the pathway overview scheme to view the reactions of a specific branch. blueTB reaction charts are interactive; clicking on a formula brings up a 3D-molecular model of the corresponding structure, clicking on a enzyme name shows its entry in the KEGG Enzyme database. The name of the coding gene is listed in bold on the right side. In case the structure of the corresponding Mycobacterium tuberculosis protein has been solved, the gene name is underlined and its blueTB entry can be accessed by clicking. 
Mycolic acids are long-chain, α-alkyl, β-hydroxyl fatty acids that form a major component of the Mycobacterium tuberuclosis cell wall. Chain lengths in Mtb-mycolic acids are typically 24 C in the alkyl-chain and 50 C to 60 C in the mero-part chain. The number of CH2-groups between the cyclopropanes (left to right) is 19 - (10,14,16) - (11,13,17,19) (Ref.) copyright Paul Imboden, Dr. PI Bioconsulting |
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part 1 | part 2 | myc pathway |
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Trehalose is a disaccharide that is made by linking two glucose molecules head to head (therefore nonreducing). It is a natural component of plants, algae, fungi and bacteria. |
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part2 | myc pathway |
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The mycobacterial cell wall is a bilayer in which the outer layer is composed of α,α'-trehalose dimycolate (cord factor), other noncovalentrly bound lipids and various proteins. The inner layer is composed of mycolic acids covalently linked to D-arabino-D-galactan and peptidoglycan. The cell wall of M. tuberculosis is extremely hydrophobic and forms a strong barrier for the difffusion of small molecules (e.g. many antibiotics) into the cytoplasma of the cell. |
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molecules | myc pathway |
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